The nuclear mole

The eye of the mole.

Mole Tar

Downloa ent advances in understanding the role of eukaryotic translation initiator factor 4E (eIF4E) in igenesis and cancer progression have generated significant interest in therapeutic agents that ctly or directly target aberrant activation of eIF4E in cancer. Here, we address the general function 4E in translation initiation and cancer, present evidence supporting its role in cancer initiati...

Mole Evid

Downlo ptive response (AR) is a term describing resistance to ionizing radiation–induced killing or formation of nt chromosomes that is mediated by pre-exposure to low ionizing radiation doses. The mechanism of ains elusive. Because cell killing and chromosome aberration formation derive from erroneous procesf DNA double-strand breaks (DSB), AR may reflect a modulation of DSB processing by nonh...

Mole Tar

Download wth factors and many oncogenes activate the lipid kinase phosphoinositide 3-kinase (PI3K), ing a signaling cascade that includes the protein kinases AKT and target of rapamycin (TOR). The AKT/TOR signaling pathway is a significant contributor to disease in various human cancers, includmatologic malignancies. Here we discuss different strategies to inhibit TOR for the treatment of ia, l...

Ruptured Complete Hydatidiform Mole in the Fallopian Tube

Tubal pregnancies are common but presence of hydatidiform mole in tube is a rare entity. A woman of 53years presented with acute abdomen, preoperative pregnancy test was positive and ultrasonography suspected the case as hydatidiform mole in right tube. The patient was treated with total abdominal hysterectomy with bilateral salpingo-oophorectomy as her family was completed. Subsequent histopat...